She won a number of national competitions and participated in a number of international festivals. She played and recorded with many Moravian dulcimer musicians, chamber ensembles and orchestral ensembles. She recorded and took part in four dozen titles, her last CD Rozchody - váváty (Zuzana Lapčíkova Kvintet) won the Anděl Music Award 2011. She also devoted herself to folk dance - in Bílovice near Uherské Hradiště she led the ethnographic group Včelaran for 17 years (two-time laureate of the Strážnice IFF).

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She is a founding member of the trio Ad Lib Moravia, an open group of musicians around the jazz pianist and composer Emil Viklický. In 2000, she recorded the CD Morava in New York with George Mráz, Billy Hart and Emil Viklický, which received an extraordinary response in the jazz world, and in 2002 she performed at Prague Spring with the George Mráz Quartet. Since 2000, he has intensively collaborated with the excellent double bassist, dulcimer and composer Josef Feč (in 2007 they initiated the creation of the ensemble Zuzana Lapčíková Kvintet). At Smetana Litomyšl 2007, she premiered her oratorio Orbis pictus based on texts by Jan Amos Komenský. As a dulcimer player, she has also been intensively engaged in teaching activities (Zlín, Uherské Hradiště) for almost twenty years. In 2009, she accepted director Václav Kadrnka's offer to portray the character of a mother in the film Eighty Letters. The chamber feature film premiered at the 2011 Berlinale and won seven international festival awards. Zuzana Lapčíková's collaboration with the theater world lasts more than 10 years.